随着时间的推移,儿童无皮炎发病率和风险因素的变化:来自两个德国出生队列的结果
Zhuoxin Peng1, Linda P Siziba1, Hermann Brenner2
1Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany.
儿童亚托皮性皮肤炎 (AD) 发病率在十年内保持稳定. 需要进一步的研究来探索环境和微生物群因素对AD发展的影响.
科学领域:
- 流行病学 流行病学
- 皮肤病学 皮肤病学
- 过敏学 过敏学
背景情况:
- 亚托邦性皮肤炎 (AD) 是儿童普遍存在的过敏性皮肤疾病.
- 评估儿童AD发病率和风险因素的长期趋势对于公共卫生至关重要.
- 了解AD患病率的长期变化有助于制定有效的预防和治疗策略.
研究的目的:
- 为了评估10年时间内儿童类皮肤炎 (AD) 累积发病率的变化.
- 识别和分析与两个不同的出生队伍儿童的AD发展相关的风险因素.
- 为了比较十年间招募的队列之间的AD发病率和风险因素关联.
主要方法:
- 利用了来自两个方法上相似的德国出生队列的数据:乌尔姆出生队列研究 (UBCS,2000/2001) 和乌尔姆SPATZ健康研究 (2012/2013).
- 通过使用日志等级测试,医生和家长报告的4岁至4岁的AD累积发病率的比较.
- 基于员工倾向分数的权衡来控制混因子和多变量考克斯回归模型来评估风险因素.
主要成果:
- 医生报告的AD (27.4%对26.4%) 和家长报告的AD (14.5%对16.7%) 的4年累积发病率在UBCS和SPATZ队列之间没有显著变化.
- 虽然AD与某些风险因素 (例如,家族史,婴儿抗生素使用) 之间的关联似乎发生了变化,但这些发现需要谨慎解释.
- 样本规模有限,消耗率和人口差异需要仔细考虑观察到的关联.
结论:
- 在观察到的十年中,儿童亚托皮性皮肤炎的发病率保持稳定.
- 需要进一步的研究来调查环境和微生物群相关因素在阿尔茨海默病发展中的潜在越来越重要的作用.
- 需要使用更大的样本大小进行纵向研究来证实这些发现,并阐明不断变化的AD风险因素.
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