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肥胖与骨折患病率之间的关联:中国的一项基于人口的横截面研究

Wenting Qi^1,2, Lijia Cui¹, Xiangjun Yin³

¹Department of Endocrinology, Key Laboratory of Endocrinology, National Commission of Health, The State Key Laboratory for Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100730, China.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

|April 28, 2025

概括

肥胖与更高的骨密度有关,但增加了脊椎骨折的风险,特别是在女性中. 身体质量指数 (BMI) 和骨折患病率之间存在U形关系.

科学领域:

内分泌学在内分泌学.
整形外科整形外科整形外科
公共卫生公共卫生

背景情况:

肥胖通常与增加的骨质量有关,但最近的发现表明存在复杂的关系.
了解身体质量指数 (BMI) 对骨健康和骨折风险的影响对于公共卫生倡议至关重要.

研究的目的:

调查中国大陆人口中肥胖和骨折患病率之间的关联.
探索BMI与骨矿物质密度 (BMD) 和骨折风险之间的非线性关系.

主要方法:

这是一项对来自COPS队列的8251人进行的横截面研究,按BMI分类.
使用五重复的坐立测试 (5R-STS) 和 Sharpened Romberg测试来评估平衡能力.
脊椎骨折 (VFs) 通过X射线证实;普遍的骨折自我报告. 使用限制立方线 (RCS) 和回归分析.

主要成果:

肥胖与骨循环减少和非线性 BMD 增加相关,在高 BMI 处停滞.
肥胖个体,特别是女性,表现出更差的平衡和更高的VF的可能性 (OR=1.88) 和普遍的骨折 (OR=2.18).
在BMI和常见骨折之间观察到U形关系,肥胖和体重不足的个体都有增加的风险.

结论:

肥胖与更高的BMD非线性相关,但增加了脊椎骨折的风险.
体重指数和普遍的骨折之间的U形关联凸显了体重不足和肥胖极端的风险.
这些发现强调了中国人口中体重,骨密度和骨折风险之间的复杂相互作用.

关键词:

平衡能力:平衡的能力是平衡能力.骨矿物质密度骨矿物质密度骨折骨折骨折骨折在肥胖问题肥胖问题骨质疏松症是一种骨质疏松症.

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