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乳酸代谢和乳酸化在乳腺癌:机制和影响

Yifan Qiao^1,2,3, Yijia Liu^1,2,3, Ran Ran^1,2,3

¹Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Cancer metastasis reviews

|April 28, 2025

概括

乳酸盐是葡萄糖代谢的产物,它调节蛋白质的乳酸和影响癌症. 本综述探讨了乳酸盐的使用情况.

科学领域:

生物化学生物化学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

乳酸是癌症的关键代谢物,由改变的葡萄糖代谢 (Warburg效应) 引起.
乳腺癌中异常的乳酸积累表明蛋白质乳糖化可能存在失调.
乳酸酸作为能量来源,信号分子,以及蛋白质乳酸化调节剂.

研究的目的:

审查癌症中蛋白质乳糖化证据.
为了突出乳酸在乳腺癌瘤微环境中的作用.
详细介绍各种瘤中的乳糖化水平和促进癌症的机制.

主要方法:

关于乳酸代谢和疾病研究的文献综述.
对不同瘤类型中乳化现有研究的分析.
综合关于乳酸的功能和干预策略的信息.

主要成果:

乳酸盐涉及蛋白质乳酸化,影响瘤的进展.
由于乳酸代谢发生变化,在瘤组织中观察到异常乳化.
乳酸和乳酸化在瘤微环境中起着重要的作用.

结论:

乳酸作为能量基质和乳酸酶的调节者的双重作用在癌症中至关重要.
了解乳化机制为癌症干预提供了潜在的治疗点.
进一步研究瘤中的乳糖化是有必要的.

关键词:

乳腺癌是什么? 乳腺癌是什么?药物药物药物是一种药物.乳酸盐是一种乳酸盐.乳化乳化乳化在此之前,TME的

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