在阻塞性睡眠呼吸暂停患者中,睡眠时间和高血压风险之间的关联
Yi Wang1,2,3, Xi Xi Chen1,2,3, Fang Ying Lu1,2,3
1Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
NPJ primary care respiratory medicine
|April 28, 2025
概括
客观的睡眠时间,而不是主观的睡眠时间,与阻塞性睡眠呼吸暂停 (OSA) 患者的高血压风险有关. 较短的客观睡眠时间与更高的高血压患病率和发病率相关.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是已知的高血压风险因素.
- 睡眠时间是一个可修改的因素,但睡眠误解在OSA中复杂化了它的作用.
- 在OSA中,主观与客观睡眠时间和高血压之间的关联尚未得到充分理解.
研究的目的:
- 调查客观和主观睡眠时间与OSA患者的高血压患病率/发病率之间的关系.
- 为了比较不同睡眠时间测量对高血压风险的预测值.
- 为了告知OSA中高血压的临床风险评估.
主要方法:
- 对睡眠心脏健康研究队列数据的分析.
- 通过客观 (PSGTST) 和主观 (AMTST,HABTST) 睡眠时间对OSA患者 (AHI ≥ 15) 的分类.
- 评估基线高血压的患病率和5.25年的发病率.
- 使用多变量逻辑回归,Poisson日志链接模型和受限制的立方线.
主要成果:
- 较短的客观睡眠时间 (PSGTST) 与高血压患病率 (p=0.009) 和发病率 (p=0.024) 的增加有线关联.
- 习惯性睡眠时间 (HABTST) 与高血压患病率呈现出U形关系.
- 早晨报告的睡眠时间 (AMTST) 与高血压结果没有显著相关.
- 客观睡眠时间显示出比主观措施更强大,更一致的关联.
结论:
- 客观睡眠时间是OSA患者高血压患病率和发病率的重要,独立预测指标.
- 对主观睡眠时间的测量对评估这一群体的高血压风险不那么可靠.
- 客观的睡眠评估对于OSA患者的高血压风险分层有价值.
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