评估精神分裂症认知评分尺度的评估者间可靠性:一个非干预性定量研究
Sebastien Tulliez1, Stella Karantzoulis2, James C Marcus3
1Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.
Schizophrenia (Heidelberg, Germany)
|April 28, 2025
概括
精神分裂症认知评分表 (SCoRS) 显示了在评估精神分裂症患者认知功能的卓越可靠性. 这支持其在临床试验中用于测量治疗有效性的使用.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 认知障碍显著影响精神分裂症患者的日常功能.
- 准确评估与认知相关的功能障碍对于治疗开发至关重要.
- 这项研究评估了精神分裂症认知评分尺度 (SCoRS) 的评分间可靠性 (IRR).
研究的目的:
- 为了确定精神分裂症认知评分尺度 (SCoRS) 的评分间可靠性 (IRR).
- 评估SCoRS在涉及精神分裂症患者的临床试验中是否适合使用.
主要方法:
- 采用了量化,非干预性研究设计.
- 经过培训的评级人员对44名精神分裂症患者及其研究伙伴进行了现场采访.
- 采访被记录下来,并由三个评级者独立评估;IRR是使用阶级间相关性 (ICC) 计算的.
主要成果:
- 在SCoRS总得分显示中度至中度严重的认知障碍,患者之间具有很高的变化.
- 该SCoRS总分获得了优异的评级者之间的可靠性,ICC为0.91.
- 该规模在不同评级者之间显示出高度的一致性.
结论:
- 20项的SCoRS总分显示出在评估精神分裂症认知相关功能能力时的卓越的IRR.
- 这些发现支持SCoRS作为精神分裂症临床研究的可靠终点.
- SCoRS是评估精神分裂症研究中的认知功能的一个有价值的工具.
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