针对中部周围皮质皮层的皮层厚度的自动细分
Nicolas A Henzen1,2, Ahmed Abdulkadir3,4,5, Julia Reinhardt6,7,8
1University Department of Geriatric Medicine FELIX PLATTER, Burgfelderstrasse 101, 4055, Basel, Switzerland. Nicolas.Henzen@felixplatter.ch.
Scientific reports
|April 28, 2025
概括
这项研究开发了一种自动化工具,用于测量阿尔茨海默病 (AD) 中的大脑结构变化. 该工具准确地检测到关键区域的缩,如中枢周围大脑皮质,帮助早期诊断AD.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 阿尔茨海默氏病 (AD) 涉及渐进的神经纤维状 (NFT) 的传播,从中枢围膜皮质 (mPRC) 开始.
- 由于与神经元损失的联系,mPRC是潜在的阿尔茨海默病早期诊断标记物.
- 测量mPRC皮层厚度的自动化工具是有限的.
研究的目的:
- 开发和验证一种自动化工具,用于测量AD易受伤害的大脑区域的皮质厚度.
- 评估自动测量的实用性,以检测阿尔茨海默氏症痴呆和轻度认知障碍中的结构变化.
主要方法:
- 利用nnU-Net框架对126名成年人的结构性MRI数据训练模型.
- 将训练有素的模型应用于103名成年人的独立数据集 (阿尔茨海默氏症痴呆症,记忆力轻度认知障碍 (aMCI) 和健康对照).
- 将自动化皮质厚度测量与手动细分进行了比较,并分析了群体差异.
主要成果:
- 实现了自动和手动皮质厚度测量之间的高度一致.
- 与对照人群相比,在阿尔茨海默氏症痴呆症中确定了显著的mPRC,内皮层 (ERC) 和侧面周内皮层 (lPRC) 缩.
- 与健康对照组相比,aMCI组中发现了显著的ERC缩.
结论:
- 开发的自动化细分工具显示出高精度和与手动测量一致.
- 该工具有效检测与阿尔茨海默病和aMCI相关的区域性脑缩.
- 这种自动化方法可以显著推进阿尔茨海默病的研究和早期诊断.
相关概念视频
01:11Papillary Dermis
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
01:15Reticular Dermis
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...