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来自2022年澳大利亚疫情的日本脑炎病毒基因型4分离的特征

Wilson Nguyen1, Narayan Gyawali1, Romal Stewart1

  • 1QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4029, Australia.

Npj viruses
|April 28, 2025
PubMed
概括

一种新的日本脑炎病毒 (JEV) 基因型4菌株 (JEVNSW/22) 在小鼠中毒性较小,但感染人类大脑器官. 现有的JEV疫苗可能会提供保护,但中和抗体反应是不理想的.

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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