不一致的植物动力学和时空传播模式驱动着人类冠状病毒的长期持久性和进化
Marcus G Mah1, Michael A Zeller1,2, Rong Zhang1
1Programme in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore, Singapore.
Npj viruses
|April 28, 2025
概括
人类冠状病毒HCoV-229E和HCoV-OC43由于更强的选择而增加了遗传多样性和传播. 其他HCoV如NL63和HKU1表现出较慢的进化和区域持久性.
科学领域:
- 病毒学 病毒学
- 分子流行病学分子流行病学
- 基因组进化 基因组进化
背景情况:
- 在全球范围内流传着四种人类冠状病毒 (HCoV).
- 了解HCoV分子流行病学和基因组进化至关重要,特别是在SARS-CoV-2后.
- 有限的数据存在于常见的HCoVs的进化动态.
研究的目的:
- 研究常见HCoVs的分子流行病学和基因组进化.
- 为了比较不同HCoV物种之间的进化模式.
- 了解推动HCoV多样化和传播的因素.
主要方法:
- 从人类鼻腔上皮细胞中分离和对HCoVs的基因组测序.
- 利用了来自新加坡和坦桑尼亚的回顾性队伍.
- 应用植物动力学推断来分析基因组数据.
主要成果:
- 自2000年代初以来,HCoV-229E和HCoV-OC43呈现出增加的遗传漂移和多样化.
- 这些病毒显示净化选择减少,特别是在尖端蛋白域A和B中.
- HCoV-NL63和HCoV-HKU1的基因漂移较弱,区域性持续性较强.
- HCoV-229E和HCoV-OC43的有效生殖数量较高 (Re>1.0).
结论:
- HCoV-229E和HCoV-OC43显示出产生新变种的更大能力.
- 持续的遗传漂移,重组和迁移促进了HCoV-229E和HCoV-OC43.3的洲际传播.
- HCoV-NL63和HCoV-HKU1遵循不同的进化轨迹,具有长期的区域持久性.
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