无人机能提供有效的早期节律控制:使用EAST-AFNET 4标准对ATHENA试验的特点分析
Paulus Kirchhof1,2,3, A John Camm4, Harry J G M Crijns5
1Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
概括
在早期心房动 (AF) 患者中,dronedarone显著降低了心血管事件. 早期的节律控制用dronedarone是支持为选定的早期AF患者.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在ATHENA试验 (NCT00174785) 中,研究了无人机对心房动 (AF) 的治疗.
- 在EAST-AFNET 4试验 (NCT01288352) 中,确定了AF早期节律控制的标准.
研究的目的:
- 评估Dronedarone (每天两次400毫克) 是否改善了患有并发症的早期心房/心房 (AF) 患者的心血管结果.
- 根据EAST-AFNET 4的纳入标准和结果评估dronedarone的疗效和安全性.
主要方法:
- 对ATHENA试验的后期分析,该试验涉及1810名早期AF患者.
- 共同初级结局包括心血管死亡,中风或因心力衰竭/急性冠状动脉综合征住院的综合结果,以及每年住院的夜晚.
- 二级结局是12个月后的鼻节律;初级安全结局是死亡,中风或与节律控制治疗相关的严重不良事件的复合.
主要成果:
- 德罗内达龙显著降低了心血管死亡,中风或住院住院的复合情况 (HR 0.71;P=0.014).
- 两组之间在医院住院的夜晚没有差异.
- 更多的Dronedarone患者实现了鼻节律 (69.2%) 与安慰剂 (60.8%).
- 在Dronedarone和安慰剂组之间,主要安全事件没有显著差异.
结论:
- 在早期AF患者中,德罗内达龙在减少心血管事件方面表现出有效性.
- 这些发现支持在精选的早期AF患者中使用dronedarone的早期节律控制治疗.
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