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Updated: May 9, 2025

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Published on: December 10, 2021

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Wnt5a诱导了ROR1依赖的NF-κB激活,以增强MMP-9表达和慢性淋巴细胞白血病的侵入性

Md Kamrul Hasan1, George F Widhopf Ii2, Emanuela M Ghia2

  • 1Center for Novel Therapeutics, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. k0hasan@ucsd.edu.

Leukemia
|April 28, 2025
PubMed
概括

矩阵金属蛋白酶-9 (MMP-9) 有助于慢性淋巴细胞白血病 (CLL) 细胞扩散. 向ROR1蛋白与zilovertamab阻断Wnt5a诱导的MMP-9,抑制CLL细胞入侵.

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