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Updated: May 9, 2025

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
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斐济HIV-1流行病的分子流行病学

Atlesh Sudhakar1,2, Donald Wilson1, Rachel Devi3

  • 1Fiji Institute of Pacific Health Research, Fiji National University, Suva, Fiji.

Npj viruses
|April 28, 2025
PubMed
概括

了解斐济的人类免疫缺陷病毒1型 (HIV-1) 疫情至关重要. 分子流行病学揭示了HIV-1亚型C群和传播模式,为有针对性的公共卫生干预提供了信息.

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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