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细胞内代谢梯度决定了对外源性pyruvate的依赖

Benjamin T Jackson1,2, Angela M Montero1,3, Sangita Chakraborty1

  • 1Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature metabolism
|April 28, 2025
PubMed
概括

纯粹的胚胎干细胞由于高的线粒体消耗,独特地依赖于外部的酸盐. 恢复细胞NAD+水平减轻了这种依赖于酸盐的情况,揭示了关键的代谢脆弱性.

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