相关实验视频

Updated: May 9, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

早期慢性阻塞性肺病的多奥米克特征

Bolun Li¹, Jiangfeng Liu², Yinghao Cao²

¹State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.

Respiratory research

|April 28, 2025

概括

这项研究使用多omics分析确定了早期慢性阻塞性肺病 (COPD) 的新生物标志物. 这些标志物改善了早期的COPD诊断,并根据炎症和血管路径揭示了不同的患者亚组.

科学领域:

肺部医学肺部医学
生物标志物发现发现
多主题研究研究多主题研究

背景情况:

慢性阻塞性肺病 (COPD) 是全球主要的死亡原因,早期诊断对管理至关重要.
目前的早期COPD (ECOPD) 诊断依赖于肺功能和吸烟史,这可能不完全反映疾病的进展.
黄金指南倡导生物标记者超过临床症状,以改善早期检测.

研究的目的:

通过多学科的方法探索ECOPD的生物特征.
为了识别与ECOPD相关的血蛋白和代谢物签名.
调查多omics数据对于ECOPD分组和肺功能预测的潜力.

主要方法:

88名ECOPD患者和88名健康对照患者的血样本的蛋白质组学和代谢学分析.
无变逻辑回归和基因组丰富分析以确定重要的蛋白质.
机器学习模型和相似性网络融合用于子组分析和预测.

主要成果:

蛋白质学确定了与ECOPD相关的248种蛋白质,主要涉及炎症.
代谢组学将137种代谢物与ECOPD联系起来.
一个多omics方法最好地预测了肺功能 (R2=0.74),而蛋白质组单独诊断了ECOPD (AUC=0.949).
确定了两个ECOPD亚组:一个是由炎症免疫反应驱动的,另一个是由血静/血管光滑肌肉标志物驱动的.

结论:

多学科整合为区分ECOPD子组提供了一个强大的策略.
已识别的蛋白质和代谢物签名对早期ECOPD诊断和风险分层有希望.
这项研究促进了对ECOPD异质性和潜在治疗点的理解.

更多相关视频

Author Spotlight: Development and Characterization of an In Vitro Model to Study Chronic Cigarette Smoke Exposure and Its Impact on Airway Epithelial Cells in COPD Research

Author Spotlight: Development and Characterization of an In Vitro Model to Study Chronic Cigarette Smoke Exposure and Its Impact on Airway Epithelial Cells in COPD Research

Published on: July 12, 2024

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

相关概念视频

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

COPD: Pathogenesis and Clinical Features

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...