经过外科手术期间的EOX治疗和胃癌前期手术后的短期和长期结果:一个单中心倾向得分匹配的队列研究
Johan Back1, Ville Sallinen2,3, Akseli Bonsdorff2
1Department of Abdominal Surgery, Helsinki University Hospital and University of Helsinki, Meilahti Tower Hospital, Building 1, Haartmaninkatu 4, PO Box 340, Helsinki, 00029 HUS, Finland. johan.back@hus.fi.
BMC surgery
|April 28, 2025
概括
术后EOX化疗是安全的,可以减少胃癌患者的瘤大小和淋巴结转移. 然而,这种下降阶段效应并没有导致改善长期生存结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 尽管进行了彻底的手术,但在西方国家,胃癌 (GC) 的生存率很低.
- 随机试验表明,外科手术期间的化疗可以通过降低疾病阶段来改善生存率.
- 这项研究比较了前期手术 (US) 与周围手术EOX化疗,随后进行GC手术.
研究的目的:
- 为了比较前期手术的短期和长期结果与外科手术期间的EOX化疗和胃癌手术.
- 评估术后EOX治疗在下降的胃癌的安全性和有效性.
- 为了确定术后化疗是否改善胃癌患者的长期存活率.
主要方法:
- 对310名为GC进行治疗性胃切除术的患者进行分析 (2006-2017年).
- 对EOX组 (n=105) 和美国组 (n=205) 的比较.
- 倾向性得分匹配 (PSM) 用于平衡基线特征;通过综合并发症指数 (CCI),30天死亡率,整体存活率 (OS),疾病特异性存活率 (DSS) 和无疾病存活率 (DFS) 评估结果.
主要成果:
- 在PSM之后,每组有102名患者;基线特征相似.
- EOX组的瘤显着较小,转移性淋巴结的数量较少.
- 手术后并发症和30天死亡率相似;在OS,DSS或DFS之间没有显著差异.
结论:
- 术后EOX治疗是安全的,并通过减少瘤大小和淋巴结转移来有效地降低胃癌的发展阶段.
- 尽管对瘤有好处,但术后EOX疗法并没有改善长期存活率.
- 在长期生存方面,前置手术仍然是一个可比的治疗选择.
相关概念视频
01:25Peptic Ulcer Disease V: Surgical Management and Nursing Care
153
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Surgical Interventions for Peptic Ulcer Disease
153
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
29
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
29