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Updated: May 9, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
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Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

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抑制m6的ALKBH5脱甲基酶,一种途径可以从潜伏期加强HIV-1的重新激活

Haider Ali1,2, Jakub Wadas1,2, Maryam Bendoumou3

  • 1Laboratory of Molecular Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.

Virology journal
|April 28, 2025
PubMed
概括

准N6-甲基氨酸 (m6A) 修饰增强了HIV-1从潜伏状态的重新激活. 与ALKi-3一起抑制ALKBH5增强了罗米德素的效果,为HIV-1治愈研究提供了一个新的"双击"策略.

关键词:
在 ALKBH5H5 中这是一次双重.史诗转录组学 史诗转录组学艾滋病病毒-1 艾滋病病毒-1延迟时间 延迟时间 延迟时间转录后的机制.冲击和杀死 - - 这是一件很棒的事情.m6A 一个很好的.

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