使用延长释放纳尔德或阿片类抗原剂的患者的疼痛强度及其对延长释放纳尔德治疗结果的影响
Farid Juya1, Kristin K Solli1,2,3, Line Holtan1
1Division of Mental Health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway.
The American journal on addictions
|April 29, 2025
概括
对于阿片类药物使用障碍 (OUD) 的延长释放纳勒 (XR-NTX) 不会加剧疼痛. 疼痛强度没有影响XR-NTX治疗结果,如保留或复发,挑战了先前的担忧.
科学领域:
- 药物中毒药物 药物中毒药物
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 阿片类药物使用障碍 (OUD) 治疗通常涉及管理同时发生的疼痛.
- 延长释放纳勒 (XR-NTX) 是OUD的有效阿片类抗体.
- 有关XR-NTX对疼痛管理的影响存在担忧,这可能会限制其使用.
研究的目的:
- 为了检查用XR-NTX治疗的OUD患者的疼痛强度变化与阿片类激动剂治疗 (OAT) 相比.
- 为了确定不同疼痛强度轨迹的患者子组.
- 评估疼痛强度对XR-NTX治疗结果的影响.
主要方法:
- 在OUD患者 (18-65岁) 中,一项为期24周的研究将XR-NTX (n=160) 与OAT (n=151) 进行比较.
- 使用数值疼痛评分表-11 (NPRS-11) 测量疼痛强度,XR-NTX每4周一次,OAT在基线/24周一次.
- 分析采用线性混合模型和基于组的轨迹建模.
主要成果:
- 低至中度疼痛的XR-NTX患者的疼痛强度降低;高疼痛患者没有经历显著变化.
- 在OAT组24周内没有观察到明显的疼痛减轻.
- 疼痛强度与XR-NTX治疗结果 (保留,复发,阿片类药物使用,渴望) 没有关联.
结论:
- 在OUD患者中,XR-NTX不会加剧疼痛强度.
- 疼痛强度不会对XR-NTX治疗成功产生负面影响.
- 这些发现挑战了人们认为XR-NTX不适合OUD患者经历疼痛的看法.
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