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Updated: May 9, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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谷氨酸通过维持IRG1 / itaconate轴,限制了宏细胞中的NLRP3炎症酶激活和烧灭

Xiaoli Chen1, Yuanfeng Zhu1, Lin Xia1

  • 1Clinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

The FEBS journal
|April 29, 2025
PubMed
概括

缺乏谷氨激活NLRP3炎症体,通过损害IRG1/伊他康酸盐通路. 补充谷氨胺可以防止炎症和组织损伤在败血症.

关键词:
在IRG1/伊塔康酸轴上在NLRP3炎症酶体中,NLRP3炎症谷氨胺的代谢过程这就是 itaconate.热致灭症是什么?

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