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相关概念视频

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...

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相关实验视频

Updated: Jun 27, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
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在早产羊胎儿中,皮质醇度升高会影响心脏发育.

Reza Amanollahi1, Stacey L Holman1, Melanie R Bertossa1

  • 1Early Origins of Adult Health Research Group, Health and Biomedical Innovation; UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.

Experimental physiology
|April 29, 2025
PubMed
概括

胎儿皮质醇升高会改变羊胎儿的心脏发育和新陈代谢. 这可能会增加晚年心血管疾病的风险.

关键词:
心血管疾病心血管疾病皮质醇是一种皮质醇.心脏的发育,心脏的发展.怀孕期中后期的怀孕期.过早的胎儿 过早的胎儿

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相关实验视频

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科学领域:

  • 生殖生物学 生殖生物学
  • 发育生物学是发展生物学.
  • 内分泌学 在内分泌学.

背景情况:

  • 皮质醇产前升高对胎儿心脏发育和成熟至关重要.
  • 了解妊娠期间皮质醇升高的影响对于胎儿的健康至关重要.

研究的目的:

  • 研究妊娠中期晚期循环皮质醇升高对胎儿羊心脏生长和新陈代谢的影响.
  • 在输入皮质醇后,分析胎儿心脏组织中基因和蛋白质表达的变化.

主要方法:

  • 皮质醇或盐水被注入胎儿羊静脉从怀孕109天到116天.
  • 胎儿心脏组织在怀孕116天被收集用于分析.
  • 在胎儿左心室 (LV) 组织中测量了葡萄糖皮质激素度,基因和蛋白质表达.

主要成果:

  • 皮质醇输注增加了心脏皮质醇度,但降低了葡萄糖皮质醇受体 (GR) 异型的调节.
  • 心脏超塑性生长的标记物被调低,而DNA复制标记物被调高.
  • 电子输送链组件,葡萄糖输送器GLUT-4和酸化IRS-1的表达得到了上调.
  • PDK4的基因表达和心血管保护标记 (SIRT-1,HO1,LAMP1,SK1) 的基因表达下调.

结论:

  • 在早产胎儿中,慢性皮质醇暴露会改变心脏发育,促进成熟.
  • 如果这些变化持续下去,这些变化可能会增加成年期心血管疾病的风险.