石榴对血管内皮功能的影响:临床试验的系统审查和元分析
Asma Kazemi1, Noushin Deylami2, Sara Shojaei-Zarghani3
1Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Journal of dietary supplements
|April 29, 2025
概括
石榴补充剂显著降低了细胞间粘附分子1 (ICAM-1) 和干白素6 (IL-6) 的水平. 然而,它对血管细胞粘附分子1 (VCAM-1) 没有显著影响.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 血管内皮功能对于心血管健康至关重要.
- 标记物如ICAM-1,VCAM-1和IL-6是内皮功能障碍的关键指标.
- 石榴因其抗氧化和抗炎性质而闻名.
研究的目的:
- 系统地审查和分析关于石榴对血管内皮功能标记物的影响的临床试验.
- 评估石榴对特定生物标志物的影响,包括ICAM-1,VCAM-1,IL-6等.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Cochrane Library) 进行了全面的文献搜索,截至2024年9月.
- 包括随机对照试验,评估石榴对成年人内皮功能标志物的影响.
- 随机效应元分析被用来汇集数据并计算标准化平均差异 (SMD).
主要成果:
- 这项分析包括了19项研究.
- 石榴显著降低了细胞间粘附分子1 (ICAM-1) 的水平 (SMD: -0.63).
- 观察到Interleukin 6 (IL-6) 的显著降低 (SMD: -0.58),而对VCAM-1 的影响并不显著.
结论:
- 石榴的消费有效地改善了内皮功能障碍的关键标志物,特别是IL-6和ICAM-1.
- 目前的证据表明,石榴不会显著影响VCAM-1水平.
- 需要进一步的研究来澄清对其他标志物的影响,如口热和NO.
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