相关实验视频
Updated: May 9, 2025

08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
6.9K
患有低骨矿物质密度的患病率和预测因素在儿科炎症性肠病中
Sharmistha Rudra1,2, Kanak Kennedy1, Sarah Neukrug1
1Division of Gastroenterology, Hepatology, & Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Journal of pediatric gastroenterology and nutrition
|April 29, 2025
概括
低骨矿物质密度 (BMD) 影响7%的儿科患者患有炎症性肠病 (IBD). 较低的BMI和身高Z分数是关键预测指标,这表明需要在这个人群中定期监测BMD.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 骨的新陈代谢 骨的新陈代谢
- 炎症性肠道疾病研究研究
背景情况:
- 对于被诊断患有炎症性肠病 (IBD) 的儿童和年轻人来说,骨健康是一个重大问题.
- 炎症性肠病 (IBD) 由于各种因素,包括炎症,营养不足和药物副作用,可能会对骨矿物质密度 (BMD) 产生负面影响.
研究的目的:
- 为了确定患有IBD的儿科和年轻成人患者队列中低骨矿物质密度 (BMD) 的患病率.
- 在这个人群中确定与骨健康状况下降相关的临床和遗传预测因素.
主要方法:
- 对600名患有IBD的患者 (3.5-22岁) 的回顾性分析,这些患者在2006年至2019年期间接受了双能量X射线吸收计 (DXA) 扫描.
- 逻辑回归确定了低BMD (Z-score ≤ -2 SD) 的预测因素,而线性回归则在378名患者的子集中检查了遗传风险得分和BMD之间的关联.
主要成果:
- 根据脊柱骨矿物质表面密度 (BMAD) 评估的低BMD的患病率在研究队列中为7%.
- 较低的BMI Z-score (OR:0.67) 和较低的身高 Z-score (OR:0.6) 是低BMAD的显著预测因素.
- 在一个纵向子集中,低BMI (OR:0.44) 和类固醇使用 (OR:3.42) 与低于最佳的骨健康 (Z-score ≤-1 SD) 有关,骨健康的遗传风险与BMD有关.
结论:
- 儿科IBD患者的下体质指数 (BMI) 需要使用双能量X射线吸收计 (DXA) 监测骨密度.
- 遗传倾向可能有助于识别患有IBD的儿科患者的特定亚群,这些儿童具有较高的骨健康下降风险.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
223
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
223
Inflammatory Bowel Disease II: Crohn's Disease
124
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
124
Inflammatory Bowel Disease I: Ulcerative Colitis
93
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
93
Inflammatory Bowel Disease IV: Pharmacological Management
79
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
79
Chronic Bowel Disorders: Introduction
300
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
300
Bone Disorders
3.3K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.3K

