当前针对局部晚期和转移性基底细胞癌的治疗选择. 一个叙事审查
Gilles Absil1, Andrée Rorive2, Nathalie Marchal2
1Departments of Dermatology, Skin Cancer Center, ICAB, University Hospital Centre, CHU du Sart Tilman, Liège, Belgium.
Expert review of anticancer therapy
|April 29, 2025
概括
局部晚期和转移性基底细胞癌 (BCC) 是具有挑战性的皮肤癌. 治疗选择范围从支持性护理到免疫疗法,常常建议使用刺抑制剂.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 基底细胞癌 (BCC) 是最常见的皮肤癌.
- 局部晚期 (laBCC) 和转移性 (mBCC) 形式很少见,但难以治疗.
- 这些情况显著影响患者的生活质量,特别是在老年人和脆弱的个体中.
研究的目的:
- 审查目前和未来的laBCC和mBCC的治疗策略.
- 讨论管理的局限性,实用性和财务方面.
- 为最佳治疗顺序提供专家意见.
主要方法:
- 审查现有的文献和治疗指南.
- 讨论治疗方法,包括免疫疗法,刺抑制剂,手术,放射治疗和电化学疗法.
- 考虑新兴疗法,如CAR-T细胞和抗LAG疗法.
主要成果:
- 有一系列的治疗选择,从支持性护理到先进的免疫疗法 (例如,抗编程细胞死亡蛋白-1 [PD-1]).
- 口服刺抑制剂 (vismodegib,sonidegib) 和其他干预措施,如电化疗,放射治疗和手术可用.
- 新的组合疗法和免疫疗法正在研究中.
结论:
- 对laBCC和mBCC的管理决策是由多学科团队做出的.
- 专家建议,当手术或放射治疗是不可行的时,优先考虑连续的刺抑制剂治疗.
- 目前正在进行的研究旨在扩大这些具有挑战性的皮肤癌的治疗选择.
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