与代谢功能障碍相关的肥胖性肝病与加速的大脑衰老有关:基于人口的研究
Jiao Wang1,2, Rongrong Yang2,3, Yuyang Miao4
1Center of Gerontology and Geriatrics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与加速的大脑衰老有关. 低度炎症可能部分解释了这种联系,强调肝脏健康对认知功能的重要性.
科学领域:
- 神经科学是一个神经科学.
- 肝病学 肝病学是一种肝病学.
- 老年学是一门学科.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越多地因其系统性影响而得到认可.
- 现有研究表明,MASLD与认知衰退之间存在相关性,包括痴呆风险.
- 马斯尔德对大脑衰老的具体影响和潜在的机制,如炎症,需要进一步调查.
研究的目的:
- 调查MASLD与加速大脑衰老之间的关联.
- 探索低度系统性炎症在这种关系中的潜在调解作用.
- 分析不同的人口和遗传子组之间的这些关联.
主要方法:
- 利用了30386名没有慢性神经疾病的参与者的英国生物库数据.
- 评估了MASLD状态和分类的亚型,包括代谢性脂肪性肝病与增加的酒精摄入量 (MetALD).
- 使用机器学习对1079个脑MRI表型进行大脑年龄估计,并计算大脑年龄差距 (BAG). 使用血液标志物评估低级炎症 (INFLA).
主要成果:
- 24.2%的参与者患有MASLD/相关的SLD.
- MASLD/相关的SLD与大脑年龄差距 (BAG) 显著相关,这表明大脑衰老加速 (β=0.86).
- MASLD (β=0.59) 和MetALD (β=1.57) 亚组显示出与更大的BAG有显著的关联. 低度炎症 (INFLA) 在MASLD-BAG关联中占13.53%.
结论:
- 包括MetALD在内的MASLD及其亚型与不同人群中加速的大脑衰老有关.
- 这种加速的大脑衰老甚至在中年成年人和非携带APOE ɛ4的人身上也很明显.
- 低度系统性炎症成为MASLD和加速大脑衰老之间的潜在部分调解者.
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