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扩大白细胞参数在区分急性发烧性疾病中的作用
Tandry Meriyanti1,2, Maroloan Aruan1, Glorya N D Ananda1
1Medical Laboratory Technology Department, Faculty of Health Science, Pelita Harapan University, Tangerang, Banten, Indonesia.
Advances in hematology
|April 29, 2025
概括
这项研究表明,扩展白细胞参数可以帮助区分病毒和细菌感染. 高光淋巴细胞计数 (HFLC) 有助于识别登革热,而其他参数有助于检测细菌血症.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 急性发烧性疾病是印度尼西亚等热带地区发病和死亡的主要原因.
- 发烧性疾病的非特异性症状使得在没有实验室检测的情况下对病原体的鉴定具有挑战性.
- 扩展的白细胞参数反映了对感染的免疫反应.
研究的目的:
- 分析急性发烧性疾病患者扩大白细胞参数的概况.
- 评估这些参数在区分各种急性发烧性疾病病因方面的诊断效用.
主要方法:
- 一项涉及473名患有急性发烧性疾病 (登革热,奇孔古尼亚热,伤寒热,细菌感染) 的患者的横截面分析研究.
- 使用Sysmex XN2000.分析扩展的白细胞参数:高光淋巴细胞计数 (HFLC),不成熟的粒细胞 (IG),中性粒细胞与淋巴细胞的比率 (NLR) 和细胞群数据 (CPD).
- 使用SPSS版本25进行的统计分析.
主要成果:
- 在病毒和细菌感染之间观察到HFLC,IG,NLR,NE-SFL,NE-WY和LY-Y的显著差异.
- 对于登革热感染,HFLC和LY-Y显示出显著的诊断能力 (AUC为0.753和0.646).
- 在IG,NLR,NE-WY和NE-SFL中,细菌血症的诊断能力显著 (AUC从0.656到0.876不等).
结论:
- 高光淋巴细胞计数 (HFLC) 是一种有价值的生物标志物,用于识别病毒感染,特别是登革热.
- 不成熟颗粒细胞 (IG),中性粒细胞与淋巴细胞比率 (NLR),NE-SFL和NE-WY对于区分细菌病与其他急性发烧性疾病很有用.
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