在败血症中维生素C:探索其在调节炎症和氧化应激中的作用
Kashmala Wazir1, Muhammad Abubakar2, Ayisha Anwar3
1Medicine, Lady Reading Hospital Peshawar, Peshawar, PAK.
Cureus
|April 29, 2025
概括
维生素C补充剂显著降低了败血症患者的炎症和氧化应激. 这导致了改善的临床结果,包括较低的死亡率和更短的重症监护室停留时间.
科学领域:
- 关键护理医学 关键护理医学
- 营养生物化学 营养生物化学
- 炎症性疾病 炎症性疾病
背景情况:
- 败血症是一种危及生命的疾病,其特点是过度炎症和氧化应激.
- 尽管医学取得了进展,但败血症的死亡率仍然很高.
研究的目的:
- 评估维生素C补充剂对炎症标志物,氧化应激和败血症患者临床结果的影响.
- 评估特定静脉注射和维护维生素C的疗程的疗效.
主要方法:
- 一项前性观察性研究,涉及326名成人败血症患者.
- 静脉注射维生素C (1500毫克/天) 持续14天,随后服用维持剂量.
- 在12个月内对氧化应激 (马隆迪甲) 和炎症标志物 (CRP,IL-6,TNF-α) 的连续测量.
- 临床结果的未来记录:ICU停留,器官功能障碍和死亡率.
主要成果:
- 在12个月内,IL-6,C反应蛋白 (CRP) 和马隆迪 (MDA) 水平显著降低.
- 改善了临床结果,包括降低了30天死亡率 (14.11%至6.90%),减少了器官功能障碍和更短的ICU停留时间.
- 维生素C补充与更好的结果显著相关 (β = -2.34,p = 0.012).
结论:
- 维生素C补充剂在改善败血症患者的临床结果方面显示出显著的益处.
- 治疗有效降低了氧化应激和炎症的关键标志物.
- 进一步的研究可能会支持维生素C作为败血症管理中的辅助疗法.
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