在患有帕金森病和没有帕金森病的个体中,声音变量的个体内变化
Paula Abola1, Mitchell Wolden2
1Clinical Research, University of Jamestown, Fargo, USA.
Cureus
|April 29, 2025
概括
在患有帕金森病 (PD) 和没有帕金森病 (PD) 的个体之间,个体内声音变化没有显著差异. 这表明,测量个体内的语音变化可能不是PD的可靠诊断工具.
科学领域:
- 神经学 神经学
- 语音科学 语言科学
- 生物医学工程 生物医学工程
背景情况:
- 声音变化,包括增加和闪,在帕金森病 (PD) 中很常见.
- 虽然研究了PD声音的个体间变化,但个体内变化仍未得到充分探索.
- 压力可以影响健康个体的声音变量,需要比较PD和非PD组的个体内变化.
研究的目的:
- 为了比较帕金森病 (PD) 患者和没有帕金森病 (PD) 患者之间语音变量的平均个体内变化.
- 为了确定两个群体之间的个体内语音变化是否有显著差异.
主要方法:
- 使用了"牛津帕金森病检测数据集",每个人进行多次语音测量.
- 每位参与者的连续语音测量之间的计算变化.
- 进行了独立的样本t测试,以比较PD和对照组之间语音变量的个体内变化.
主要成果:
- 在PD (n=24) 和没有PD (n=8) 个体之间的任何语音变量的个体内变化中没有发现统计学上显著的差异.
- 语音基本频率的平均差异从-1.98e5到2.58e5.5不等.
- ,闪和其他变量 (如HNR) 的平均差异也显示没有显著的群体区别.
结论:
- 个体内语音变异性并不能显著区分患有帕金森病的人与没有帕金森病的人.
- 个体内语音变化可能不是适合的PD诊断生物标志物.
- 未来的研究应该研究其他方法来评估PD的个体内语音变异性.
相关概念视频
01:15Parkinson's Disease: Overview
308
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
308
01:24Parkinson's Disease: Treatment
148
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
148
01:37Neural Regulation
39.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.0K
01:21Larynx
1.1K
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
1.1K
01:25Pulmonary Function Tests
246
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
246
01:19Factors Affecting Pulmonary Ventilation
960
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
960