代谢综合征,左心室透静功能障碍和心力衰竭与保存的射出分数
Dan Zhou1, Shuisheng Lin1, Zongchen Liu1
1Department of Geriatrics, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology; Shenzhen Clinical Research Center for Geriatrics; Guangdong Provincial Clinical Research Center for Geriatrics), Shenzhen, Guangdong, China.
Frontiers in endocrinology
|April 29, 2025
概括
代谢综合征 (MetS) 与心脏问题有关,例如左心室透静功能障碍 (LVDD),这是心力衰竭的关键部分,具有保存的射出分数 (HFpEF). 在MetS患者中早期发现心脏变化对于更好的治疗结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
- 心血管研究研究心血管研究
背景情况:
- 代谢综合征 (MetS) 涉及肥胖症,高血糖症,高脂症和高血压,由胰岛素抵抗驱动.
- 甲状腺瘤是心血管事件和死亡的主要风险因素,其全球流行率正在上升.
- 患有MetS的患者经常会出现不良的心脏改造和心肌功能障碍,即使没有阻塞性冠状动脉疾病.
研究的目的:
- 审查最近关于MetS组件或MetS与心脏衰竭中左心室透静功能障碍 (LVDD) 与保留射出分数 (HFpEF) 之间的关联的文献.
- 突出早期诊断心脏改造在MetS患者的重要性,以便及时进行治疗干预.
主要方法:
- 最近文章的文献综述. 最近文章的文献综述.
- 专注于研究检查MetS组件及其与HFpEF中的LVDD关系的研究.
- 心声成像作为评估LVDD和左心室填充压力的关键成像方式.
主要成果:
- MetS与不良的心脏重塑有关,包括左心室缩 (LVH) 和LVDD.
- 涉及的机制包括异常的心肌基质利用,神经激素激活,纤维化和炎症.
- LVDD和左心室填充压力升高是HFpEF在MetS患者中的主要表现.
结论:
- 保存喷射分数 (HFpEF) 的心力衰竭在代谢综合征 (MetS) 患者中非常普遍.
- 了解MetS和LVDD之间的联系对于管理HFpEF至关重要.
- 在MetS中早期发现心脏功能障碍对于预防疾病进展至关重要.
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