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利用生理学基础的药动力学模型来支持中国老年人群的理性药物治疗

Xiaofei Wu1, Ziyang Wang1, Shupeng Liu1

  • 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China.

Drug design, development and therapy
|April 29, 2025
PubMed
概括

对中国老年人的50种药物开发了生理学基础的药理动力学 (PBPK) 模型,解决了理性药物治疗的数据缺口. 这种方法支持个性化药物治疗和治疗药物监测 (TDM),以改善患者的治疗结果.

关键词:
在PBPK模型中,个性化医学是个性化的医学.药物动力学 药物动力学有理性的药物治疗.年长的老年人.

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