人类介质干细胞衍生的外体作为达努鲁比的工程载体,用于向c-Mpl+AML治疗
Chunmou Li1, Yuchen Wen1, Jiasheng Wang2
1Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, 518107, People's Republic of China.
International journal of nanomedicine
|April 29, 2025
概括
工程外体有效地向和消除c-Mpl+急性髓性白血病 (AML) 细胞. 这种新型药物输送系统对治疗AML具有可控副作用的有希望.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 纳米技术 纳米技术
背景情况:
- 急性髓性白血病 (AML) 具有重大治疗挑战,特别是在c-Mpl+亚型中.
- 与正常组织相比,原瘤基因c-Mpl在AML细胞中表达过度.
研究的目的:
- 开发有针对性的外体 (Exos),用于专门向c-Mpl+AML细胞输送抗癌药物.
- 为了设计具有增强准和药物输送能力的外体.
主要方法:
- 人类带介质干细胞 (hUCMSCs) 用于衍生出外体.
- 外体被设计为融合蛋白 (CD63-mTPO3),其表面准c-Mpl.
- 达努鲁比 (DNR) 被封装在向外体 (m3Exos@DNR) 中,用于药物输送.
- 向,吸收,有效性和安全性在体外和小鼠AML模型中进行了评估.
主要成果:
- 工程外体显示出高结合亲和力和c-Mpl+AML细胞的内细胞吸收.
- m3Exos@DNR在体外和体内有效消除了c-Mpl+AML细胞.
- 治疗毒性处于可接受的范围内,副作用可控.
结论:
- 工程外体代表了对c-Mpl+AML的强有力的向药物递送系统.
- 这种方法提供了有利的安全性概况和治疗AML和其他具有特定蛋白质表达的癌症的潜力.
更多相关视频
08:13Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
Published on: April 10, 2019
6.0K
09:20Differentiation of Monocytes into Phenotypically Distinct Macrophages After Treatment with Human Cord Blood Stem Cell CB-SC-Derived Exosomes
Published on: November 12, 2020
5.7K
相关概念视频
01:36Overview of Exosomes
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
01:19Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...