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肠道微生物群对结肠直肠瘤治疗的影响 (综述)
Yangyang Chen1, Nian Wu2, Xin Yan3
1General Surgery Department, Guiyang Public Health Clinical Center, Guiyang, Guizhou 550004, P.R. China.
Molecular and clinical oncology
|April 29, 2025
概括
肠道外科手术后的静脉漏 (AL) 正在增加,可能是由于肠道细菌的变化. 针对肠道微生物群的策略可能会降低AL风险并改善外科手术结果.
科学领域:
- 胃肠病学 胃肠病学
- 手术创新 在外科创新.
- 微生物组研究 微生物组研究
背景情况:
- 肠道解肠对于手术连续性至关重要,但面临着不断上升的解肠性泄漏 (AL) 率,高达20%.
- 肠道微生物组合的外科手术期间的变化越来越被认为是导致AL的重要因素.
- 肠道微生物群,宿主免疫和外科手术压力之间的复杂相互作用会影响肠道整体性.
研究的目的:
- 探索肠道微生物群变化的作用,在肠道手术后的门泄漏 (AL).
- 为了确定特定的微生物因素和宿主微生物相互作用,影响动脉的愈合.
- 通过调节肠道微生物群来审查目前和未来预防AL的策略.
主要方法:
- 文献综述侧重于研究肠道微生物群对肠道瘤的影响.
- 分析研究,将外科手术期间的微生物群变化与AL发病率和严重程度联系起来.
- 检查涉及微生物群调节的预防策略的证据.
主要成果:
- 肠道微生物组合的显著变化发生在外科手术期间,与AL风险增加相关.
- 特定的病原体,如*Enterococcus*和*Pseudomonas aeruginosa*,都与AL的发病有关.
- 在AL的病例中,观察到有益的微生物群体中对愈合至关重要的干扰.
结论:
- 肠道微生物群失生症是导致解肠漏 (AL) 的关键因素.
- 有针对性的干预措施,包括饮食改变,个性化准备和微生物群恢复,在缓解AL方面显示出希望.
- 需要进一步的研究来阐明精确的机制,并开发有效的基于微生物群的疗法,以改善手术结果.
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