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Updated: May 9, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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针对HER2的ADC的机制取决于Rab GTPases的作用

Astrid Medhus1, Kay Oliver Schink1,2, Ane Sager Longva1

  • 1Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Therapeutic advances in medical oncology
|April 29, 2025
PubMed
概括

抗体-药物联合体 (ADC) 设计影响细胞内贩运和疗效. 特拉斯图祖马布德鲁克斯泰干 (T-DXd) 处理与阿多-特拉斯图祖马布埃姆坦辛 (T-DM1) 不同,受Rab GTPases (如RAB4a) 的影响.

关键词:
这是一个ADCADC ADC.在HER2中,HER2是HER2.在RAB5中,使用RAB5的方法.这就是T-DM1的特点.在T-DXd.乳腺癌 乳腺癌 乳腺癌它们的作用机制.

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