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评估一个超便携式X射线系统与自动解释结核病活体病例在监狱设置发现的自动解释:一个诊断测试准确性研究研究

Argita D Salindri¹, José V B Bampi², Caroline Busatto²

¹Stanford University School of Medicine.

Research square

|April 29, 2025

概括

一个带有人工智能解释的便携式数字X射线系统有效地查了监禁人员的结核病 (TB). 这项技术表现出高精度,特别是在检测结核病症状方面,解决了监狱查能力缺口.

科学领域:

公共卫生公共卫生
传染性疾病传染性疾病
医疗成像医学成像

背景情况:

世界卫生组织 (WHO) 建议在高风险人群中发现结核病 (TB) 的活跃病例,包括被监禁的人.
监狱经常面临着结核病查能力不足的挑战.
这项研究评估了一种解决这一差距的新方法.

研究的目的:

为了评估超便携式数字胸部X-ray系统 (Fujifilm FDR Xair) 与用于结核病检测的自动解释算法 (LunitTB) 结合的诊断性能.
为了评估系统在现实监狱环境中的准确性.

主要方法:

在巴西一所监狱 (2023年2月至2024年5月) 开展了潜在的结核病活跃病例发现倡议的诊断测试准确性研究.
3399名没有近期结核病史的符合条件的监禁成年人使用富士FDR Xair和LunitTB算法进行了查.
通过将系统结果与严格的微生物学参考标准进行比较来确定诊断准确性,计算曲线下的面积 (AUC) 和95%置信区间 (CI).

主要成果:

该研究对3399名个人进行了查,确定结核病患病率为4.1%.
富士的FDR Xair系统与LunitTB解释实现了总体AUC为0.89 (95%CI为0.86-0.93).
与没有症状的人 (AUC = 0.87) 相比,患有结核病症状的人 (AUC = 0.93) 的诊断准确性显著更高.

结论:

超便携式数字放射学系统与LunitTB解释相结合,提供了一种快速且高度准确的结核病查方法.
这项技术特别有望在具有症状的个体中提高结核病检测能力,但在查能力有限的环境中.

关键词:

单位单位TBTB 积极的案例发现活动.被剥夺自由的人.超便携式X射线照射器超便携式X射线照射器

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