模仿结核性脑膜炎的MOG阳性原发性自身免疫脑膜炎:一个病例系列
Tejas Shivarthi1, Mahima Sriram1, Muddana Nikhilesh1
1Department of Neurology, Amrita Institute of Medical Sciences and Research Centre, Kochi, India.
BMJ neurology open
|April 29, 2025
概括
髓寡细胞糖蛋白 (MOG) IgG抗体阳性可以模仿结核性脑膜炎 (TBM). 早期的MOG抗体测试对于准确的诊断和治疗至关重要,特别是当TBM治疗无效时.
科学领域:
- 神经免疫学 神经免疫学
- 传染病流行病学 传染病流行病学
背景情况:
- 很少有记录的IgG抗体阳性呈现为原发性自身免疫性脑膜炎.
- 结核性脑膜炎 (TBM) 在许多地区是流行病,导致MOG相关疾病的潜在误诊.
研究的目的:
- 为了识别具有MOG IgG抗体阳性的患者,最初被误诊并为TBM治疗.
- 突出MOG相关脑膜炎在TBM流行地区的诊断挑战.
主要方法:
- 对MOG IgG抗体阳性病例的回顾性横截面研究.
- 对患者病历进行查,以发现类似于TBM的表现和初始抗结核疗法.
- 对临床,微生物学,放射学和血清学特征的分析.
主要成果:
- 五名患有类似TBM症状的患者被诊断出患有MOG相关的脑膜炎/脑膜炎.
- 临床表现包括头痛,吐,视力受损和虚弱.
- 核磁共振成像的结果各不相同,有些人表现为脱髓化,有些人表现为正常;MOG抗体检测要求进行序列分析.
结论:
- 与MOG相关的脑膜炎可能与TBM类似,造成诊断挑战.
- 当TBM治疗失败或复发时,考虑自身免疫病因至关重要.
- 建议立即进行MOG IgG抗体测试,以准确诊断和有效管理.
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