在Pichia pastoris中通过代谢工程和构建一个正交的能源供应系统,高效地生产2'-糖乳糖

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Yi Li1,2, Xiang Wang1,2, Kaidi Chen1,2

  • 1Center for Synthetic Biochemistry, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, 518055, China.

Synthetic and systems biotechnology
|April 29, 2025
PubMed
概括

这项研究将Pichia pastoris设计为高效的2'-糖乳糖 (2'-FL) 生产,实现了创纪录的标位. 工程酵母利用其强大的NADPH再生和甲醇代谢来增强这种重要的婴儿营养素的生物合成.

关键词:
2′-FL生物合成的方法辅助因素工程是指工程中的辅助因素.微生物细胞工厂是一个微生物细胞工厂.在正交的能量模块.

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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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