选择性STING协同效应剂的设计,合成和生物评估,可增强cGAMP-STING通路激活,没有固有的激进分子活动

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Updated: May 12, 2026

A Calcium Bioluminescence Assay for Functional Analysis of Mosquito Aedes aegypti and Tick Rhipicephalus microplus G Protein-coupled Receptors
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A Calcium Bioluminescence Assay for Functional Analysis of Mosquito Aedes aegypti and Tick Rhipicephalus microplus G Protein-coupled Receptors

Published on: April 20, 2011

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Shi Hou1, Jiajia Chang1, Cheng Xing1

  • 1State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Journal of medicinal chemistry
|April 29, 2025
PubMed
概括

研究人员开发了新的STING协同剂,以选择性地提高对癌症的先天免疫力. 化合物67表现出强大的抗瘤作用,具有出色的安全性和药理动力学,为癌症免疫治疗提供治疗潜力.

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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission07:16

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