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对肠道微生物群的时间网络分析揭示了与结肠癌相关的衰老轨迹

Ziqi Chen^1,2, Zhipeng Zhang¹, Bei Ning Nie³

¹Institute of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

|April 29, 2025

概括

肠道微生物群在结直肠癌 (CRC) 患者和健康个体之间存在差异,年龄特定的变化. 病原细菌增加,而有益的细菌减少CRC,影响疾病的进展.

科学领域:

微生物学微生物学
在瘤学瘤学.
遗传学遗传学是一个

背景情况:

人的肠道微生物组在结直肠癌 (CRC) 病变发生过程中发挥着重要作用.
衰老会影响微生物组的组成及其与CRC的关联.

研究的目的:

考虑到年龄,描述CRC患者和健康个体之间的微生物组差异.
确定CRC中的特定年龄的微生物生物标志物和功能途径.
探索微生物改变对CRC发病和进展的影响.

主要方法:

来自80名CRC患者和80名健康对照的便样本的综合元基因组测序.
分析不同年龄组 (年轻人,中年人,老年人) 的微生物组结构和功能概况.
在独立的队列中验证发现.

主要成果:

在CRC患者和健康对照人群之间观察到肠道微生物组合的显著差异,与年龄相关的变化.
在CRC患者中,致病细菌 (例如,Bacteroides vulgatus) 的患病率增加和有益细菌 (例如,Lactobacillus) 的减少.
丰富的微生物通路在CRC患者与DNA修复,细胞循环调节和新陈代谢 (例如,酸盐循环,银糖代谢) 相关.

结论:

肠道微生物组的改变与CRC病原发生有关,并受到年龄的影响.
特定的微生物特征和功能途径可以作为CRC的生物标志物.
这些发现支持开发基于微生物组的诊断和治疗方法,用于跨年龄组的CRC.

关键词:

老化的老化衰老的老化大肠直肠癌 (CRC) 是一种癌症.我们的肠道微生物组.微生物代谢物的微生物代谢物

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