核心大脑网络与第一发精神分裂症中抗精神病治疗效果的关联
Yuling Luo1, Tianyuan Zhu2, Yu Zhang1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, No. 2006, Xiyuan Avenue, High-Tech District, Chengdu 610054, P. R. China.
Cerebral cortex (New York, N.Y. : 1991)
|April 29, 2025
概括
大脑网络通信差异预测精神分裂症的抗精神病反应. 在默认模式网络 (DMN) 和中央执行网络 (CEN) 等网络中分析功能连接 (FC) 可以识别治疗子类型.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症的治疗反应是异质的,需要个性化医疗方法.
- 了解抗精神病药物的抗精神病疗效的神经生物学基础对于改善患者的治疗结果至关重要.
- 目前的研究在阐明不同抗精神病治疗反应背后的机制方面取得了有限的进展.
研究的目的:
- 调查精神分裂症患者中核心大脑网络之间静态和动态功能连接 (FC) 的差异,这些患者对抗精神病单一治疗有反应,而对抗精神病单一治疗没有反应.
- 确定潜在的神经成像生物标志物,用于预测第一发精神分裂症患者对抗精神病治疗的反应.
- 探索基线功能性大脑网络通信在缓解症状和分类响应亚型中的作用.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 数据来自79名精神分裂症患者和90名健康对照.
- 在五个核心大脑网络中对静态和动态功能连接 (FC) 的分析:默认模式网络 (DMN),中央执行网络 (CEN),突出网络 (SN),主网络 (PN) 和亚皮层网络 (SCN).
- 对抗精神病单一治疗12周前后的FC模式进行比较,使用基线FC作为调节变量.
主要成果:
- 与响应者相比,非响应者在CEN-DMN/SN和SN-SCN后处理中显著减少静态FC.
- 与响应者相比,非响应者在基线时在PN-DMN/SN中显示出显著更高的动态FC.
- 基线FC模式有效地区分了高分类准确度的响应亚型.
结论:
- 核心大脑网络内部和核心大脑网络之间的异常通信与精神分裂症患者对抗精神病单一治疗的差异反应有关.
- 基线功能连接模式具有作为预测抗精神病治疗反应和识别神经解剖学亚型的生物标志物的潜力.
- 这项研究通过突出网络间通信在治疗结果中的作用,促进了对抗精神病治疗机制的理解.
相关概念视频
01:21Antipsychotic Drugs: Therapeutic Uses and Side Effects
104
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
104
01:28Psychosis and Antipsychotic Drugs: Overview
152
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
152
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
262
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
262
01:21Antipsychotic Drugs: Typical and Atypical Agents
120
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
120
01:29Biological Causes of Schizophrenia
19
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
19
01:26Psychosis: Goals of Pharmacotherapy
95
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
95