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化疗可能影响食道Lugol染色内镜重度:回顾性队列研究和文献综述
Wen-Hung Hsu1,2,3,4, Chien-Chieh Lin1, Hsiang-Yao Shih1
1Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
The Kaohsiung journal of medical sciences
|April 29, 2025
概括
化疗可以改变食道状细胞瘤患者的卢戈尔染色体检查结果,导致变色和病变外观的变化. 仔细的解释是治疗后至关重要的.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 内镜检查是指内镜检查.
背景情况:
- 卢戈尔染色内镜对于食道状细胞新生病 (ESCN) 查和内镜下粘膜切割 (ESD) 边缘评估至关重要.
- 在癌症治疗后,ESCNs的形态变化可能会发生,这可能会影响诊断的准确性.
- 化疗对Lugol染色内镜检测结果的影响需要进一步调查.
研究的目的:
- 为了评估化疗对卢戈尔染色内镜检查结果的影响,在查和ESD期间对ESCNs进行ESD.
- 在接受ESD的患者中,在化疗前后比较Lugol染色内学结果.
- 分析染,病变大小,边缘评估和粉红色标志的特定变化.
主要方法:
- 从2009年8月到2024年3月接受ESD的162名ESCN患者的回顾性分析.
- 最初和后续的卢戈尔染色内镜检测结果的比较.
- 对化学疗法和辐射暴露数据的患者医疗记录的审查.
- 关于化疗对Lugol染色内镜的影响的文献综述.
主要成果:
- 32名患者 (19.8%) 在初始和后续评估之间显示了Lugol染色内镜检测结果的显著差异.
- 其中14名患者 (43.8%) 之前接受过化疗,其中26名患者在ESD后2个月内接受治疗.
- 化学疗法治疗的患者呈现出显著色的染色内镜检查结果 (53.8%,p < 0.01),不论辐射暴露.
- 文献支持化疗可以减少Lugol-voiding病变.
结论:
- 化疗显著影响ESCN患者的病变形态和Lugol染色.
- 化学疗法治疗患者的淡色染色内镜检测结果需要仔细解释.
- 在接受过化疗的患者中,应调整Lugol染色内镜的时间和解释.
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