BDNF与MTOR共同表达,并与肌肉纤维大小,肌肉质量和功率相关的特征有关
Celal Bulgay1, Erdal Zorba2, Hasan H Kazan3
1Sports Science Faculty, Bingol University, Bingol, Türkiye.
European journal of applied physiology
|April 29, 2025
概括
大脑衍生神经营养因子 (BDNF) 基因表达与骨肌肉中的mTOR基因表达具有正相关性. 基因预测较高的BDNF与运动员肌肉纤维大小,肌肉质量和功率表现的增加有关.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 大脑衍生神经营养因子 (BDNF) 和mTOR信号通路与蛋白质合成和肌肉生长有关.
- 在人类骨肌肉生长和功率表现中,BDNF的确切作用仍然在很大程度上未被阐明.
研究的目的:
- 为了研究BDNF和mTOR基因表达在人类骨肌肉中的关系.
- 检查基因预测的BDNF表达与肌肉特征之间的关联,包括纤维大小,瘦质量,功率表现和功率运动员状态.
主要方法:
- 分析了包括运动员和对照在内的456,382名参与者的基因表达数据.
- 通过免疫组织化学评估的肌肉纤维组成.
- 使用实时PCR或微阵列进行的BDNF基因型鉴定.
主要成果:
- 观察到BDNF和mTOR基因表达在横向巨大的肌肉中之间存在显著的积极关联 (p < 0.0001).
- 在运动员中,基因预测较高的BDNF表达与较大的快肌纤维截面面积相关 (p = 0.0069).
- 较高的BDNF表达也与尾肌肉量增加 (p = 2.6 × 10−7),力量运动员个人最佳状态 (p = 0.029) 和力量运动员状态 (p = 0.0056) 有关.
结论:
- 这项研究证实了BDNF和mTOR基因表达在人类骨肌肉中的正相关性.
- 基因预测较高的BDNF表达与增强的肌肉纤维大小,肌肉质量和优越的功率性能有关,这表明BDNF在运动功率中的作用.
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