Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Carnosinylation of Cardiac Antigens Attenuates Immunogenic Responses and Improves Function in Failing Hearts.

Journal of the American Heart Association·2026
Same author

Dietary fructose promotes MASH/HCC progression through enhanced intestinal HIF-2α-dependent iron absorption.

bioRxiv : the preprint server for biology·2026
Same author

The Ugly Side of NO: Erythrocyte-Derived NO and Atherosclerosis.

Circulation research·2026
Same author

TAK1 drives inflammatory fibroblast acquisition and shapes myocardial infarction responses in male mice.

Nature communications·2026
Same author

Cardiac Ketone Body Oxidation Enhances Exercise Performance.

Circulation research·2025
Same author

Exercise-Stimulated Resolvin Biosynthesis in the Adipose Tissue Is Abrogated by High-Fat Diet-Induced Adrenergic Deficiency.

Arteriosclerosis, thrombosis, and vascular biology·2025

相关实验视频

Updated: May 9, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

9.8K

由G-CSF诱导的紧急颗粒形成调节了小鼠中性粒细胞效应器的功能.

Jonah K Stephan1, Taylor Knerr1, Collin K Wells1

  • 1Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute, University of Louisville School of Medicine, 580 South Preston Street - Rm 204B, Louisville, KY, USA.

Stem cell reviews and reports
|April 29, 2025
PubMed
概括

由G-CSF触发的紧急颗粒形成,产生具有功能改变的中性粒细胞. 这些中性粒细胞表现出受损的活性氧物种生产和NETosis,但增强了弹性酶分泌和细胞因子表达,影响了炎症.

关键词:
细胞因子细胞因子在G-CSF中使用.颗粒构造是一种颗粒构造.血液形成 血液形成 血液形成炎症 炎症是一种炎症.作为一个中性粒细胞.

更多相关视频

Isolation and Characterization of Neutrophils with Anti-Tumor Properties
10:15

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

24.7K
Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments
07:28

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Published on: July 10, 2013

61.7K

相关实验视频

Last Updated: May 9, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

9.8K
Isolation and Characterization of Neutrophils with Anti-Tumor Properties
10:15

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

24.7K
Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments
07:28

Isolation, Purification and Labeling of Mouse Bone Marrow Neutrophils for Functional Studies and Adoptive Transfer Experiments

Published on: July 10, 2013

61.7K

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学

背景情况:

  • 中性粒细胞是关键的免疫反应者,它们的功能是在颗粒形成过程中被编程的.
  • 在严重炎症期间激活紧急颗粒形成,以满足中性粒细胞需求的增加.
  • 紧急颗粒形成对中性粒细胞的功能后果尚不清楚.

研究的目的:

  • 调查紧急颗粒形成对中性粒细胞的功能影响.
  • 评估通过紧急颗粒形成产生的中性粒细胞如何影响体内炎症反应.

主要方法:

  • 用G-CSF治疗小鼠,以诱导紧急颗粒形成.
  • 评估了中性粒细胞功能,包括ROS产生,NETosis,弹性酶分泌和细胞因子表达.
  • 用于评估G-CSF治疗小鼠的炎症反应,使用了因齐莫桑诱导的腹膜炎的体内模型.

主要成果:

  • 来自G-CSF治疗小鼠的中性粒细胞表现出ROS产量受损和NETosis.
  • 这些中性粒细胞表现出中性粒细胞弹性酶分泌量增加和促炎性细胞因子 (TNF-α,IL-1β,IL-1α,IL-12α,CCL2) 的表达升高.
  • 在体内,接受G-CSF治疗的小鼠接受了齐莫桑的挑战,表现出腹中性粒细胞CCL2表达的增加和巨细胞积累的增强.

结论:

  • 紧急颗粒形成重编程中性粒细胞,导致增强的免疫调节功能.
  • 这些中性粒细胞在局部组织炎症期间协调随后的巨细胞反应中发挥着关键作用.