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Updated: May 12, 2025

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
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同时估计fm和FG值直接来自临床药物相互作用研究数据

Yumi Cleary1,2, Nicolo Milani2, Kayode Ogungbenro1

  • 1Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK.

The AAPS journal
|April 29, 2025
PubMed
概括

两种新方法使用基质度变化估计了关键的药物相互作用参数,肝脏代谢分数 (fm) 和肠道可用性 (FG). 这些方法有助于预测药物相互作用,并为更安全的药物使用提供临床研究设计的信息.

关键词:
药物相互作用 (DDI) 是一种药物相互作用.基于模型的药物开发 (MIDD)基于生理学的药理动力学 (PBPK) 建模.

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