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对18种元素的元素比较分析揭示了良性和恶性甲状腺组织的不同模式

Xueying Liu^1,2, Linjing Huang^1,3,4,5, Youzhi Zhu⁶

¹Department of Endocrinology, the First Affiliated Hospital, Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, Fujian, China.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

|April 29, 2025

概括

甲状腺癌与不同的微量元素水平有关. 恶性组织显示较高的,和铁,而良性组织有更多的,铜和,表明潜在的诊断标记.

科学领域:

生物化学生物化学
在瘤学瘤学.
分析化学分析化学

背景情况:

微量元素在生物过程中起着至关重要的作用.
元素度的不平衡与各种疾病有关,包括癌症.
了解甲状腺组织中的元素概况可能为甲状腺瘤发生提供了洞察力.

研究的目的:

为了比较良性与恶性甲状腺组织中的18种微量元素的度.
为了确定特定的元素,这些元素在良性和恶性甲状腺瘤之间存在显著差异.
探索微量元素作为甲状腺癌生物标志物的潜在作用.

主要方法:

在106个术后甲状腺组织样本中分析了18种微量元素 (Al,Na,K,Mg,Ca,Ti,Ba,Sn,Cr,Mn,Fe,Cu,Zn,Se,Mo,Cd,Sr,Tl).
使用感应合等离子体质谱法 (ICP-MS) 量化元素度.
统计分析包括斯皮尔曼相关性,直角部分最小平方差分分析 (OPLS-DA) 和多变量逻辑回归.

主要成果:

在良性和恶性甲状腺组织之间观察到多种微量元素度的显著差异.
恶性组织显示Mg,Al,Fe,Cr,Ti,Sr,Sn和Ba的含量较高.
良性组织的Na,Mn,Cu,Zn,Cd和Mo含量较高.
OPLS-DA确定了Al,Ti,Sn作为恶性组织的歧视剂,Na,Mn,Cu,Zn,Cd,Mo作为良性组织的歧视剂.
多变量逻辑回归将甲状腺癌与Al,Cr,Ti,Sr,Sn,Ba,Mn,Cu,Zn和Cd的水平相关联.

结论:

良性和恶性甲状腺瘤表现出不同的微量元素配置.
某些元素如铜 (Cu), (Mn) 和 (Zn) 可能具有抗瘤特性.
高水平的 (Ba), (Cr) 和 (Al) 与甲状腺恶性瘤有关.
元素缺乏或过量可能是甲状腺组织恶性转变的结果.

关键词:

重金属是一种重金属.甲状腺良性结节甲状腺良性结节甲状腺癌是什么?甲状腺癌是什么?微量元素中的微量元素.

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