在晚期发作的叶中认知功能障碍的特征
Naoya Hasegawa1, Natsumi Saito2, Masafumi Fukuda3
1Department of Psychiatry, National Hospital Organization, Nishiniigata Chuo Hospital Epilepsy Center, Niigata, Japan.
概括
晚发性叶 (LOTLE) 的频繁发作会对记忆和注意力产生负面影响. 在LOTLE中,认知功能障碍可能伴随着保留的延迟回忆或短暂的性失忆.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 的研究研究.
背景情况:
- 全球人口正在老龄化,导致晚发性 (LOE) 的增加.
- 晚发性叶 (LOTLE) 是一种常见的LOE形式,通常与记忆力缺陷有关.
- 了解LOTLE中临床因素和认知障碍之间的关系对于患者管理至关重要.
研究的目的:
- 调查LOTLE患者的记忆功能和临床特征之间的关联.
- 探索长期视频脑电图 (LVEEG) 发现与LOTLE的认知表现之间的相关性.
主要方法:
- 17名被诊断患有LOTLE的患者的回顾性评估.
- 在开始服用抗发作药物之前,利用了LVEEG监测和神经心理测试,包括维克斯勒记忆量表修订版 (WMS-R).
- 进行多重回归分析以确定临床变量 (包括LVEEG数据) 和认知得分之间的关系.
主要成果:
- 由LVEEG捕获的来自左叶的发作显示出与口头记忆 (β = -0.79),视觉记忆 (β = -0.645),一般记忆 (β = -0.838) 和注意力 (β = -1.334) 有显著的负相关性.
- 经历过渡性amnestic插曲的患者在30分钟后表现出相对更好的延迟回忆得分 (β = -0.606).
结论:
- 频繁的左叶发作与LOTLE患者的各种认知功能 (包括记忆和注意力) 的损伤有关.
- 认知功能障碍模式在LOTLE中可以分为两种类型:保存的延迟回忆与暂时性记忆丧失,或损害的延迟回忆.
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