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含有Paeonia lactiflora提取物的牙刷清洁剂的抗菌有效性和生物相容性

Ji-Won Lim¹, Jiyeon Lee¹, Min-Kyung Kang²

¹Department of Health Science, Graduate School, Gachon University, Yeonsu-gu, Incheon 21936, Republic of Korea.

|April 29, 2025

概括

一种新的天然假牙清洁剂含有Paeonia lactiflora提取物显示对生物膜的有效性,与传统产品相比. 它对口腔组织是安全的,为假牙卫生和口腔健康提供了一个有希望的替代方案.

科学领域:

微生物学微生物学
生物材料科学生物材料科学
口腔健康口腔健康

背景情况:

假牙上的微生物生物膜对口腔和全身健康构成风险.
传统的化学假牙清洁剂可能会引起诸如粘膜刺激和口腔微生物组破坏等不良影响.
寻求自然替代品来减轻这些风险,同时确保有效的生物膜控制.

研究的目的:

评估一种含有Paeonia lactiflora提取物 (DC-PL) 的新型假牙清洁剂的抗菌疗效.
通过口腔粘膜刺激测试来评估DC-PL的生物相容性.
为了比较DC-PL与传统的化学清洁剂 (Polident®) 和负对照 (蒸水).

主要方法:

口腔微宇宙生物膜是使用人类唾液在六天内开发的.
生物膜每天接受DC-PL,蒸水或Polident®的治疗,持续6天.
通过红色/绿色光比和酸性细菌计数来评估抗菌活性;使用口服粘膜刺激试验测试生物相容性.

主要成果:

与蒸水相比,DC-PL显著减少了生物膜的形成 (RatioR/G),并且与Polident®可比.
与蒸水相比,DC-PL的酸性细菌数量显著降低,类似于Polident®.
DC-PL的口腔粘膜刺激指数为零,表明没有粘膜刺激.

结论:

DC-PL对假牙生物膜的抗微生物疗效与Polident®相似.
DC-PL表现出极好的生物相容性,不会引起口腔粘膜刺激.
DC-PL为假牙卫生和口腔健康管理提供了一种安全有效的天然替代品.

关键词:

这种植物是Paeonia lactiflora.抗微生物作用的抗微生物效应.生物相容性生物相容性假牙清洁剂是一种清洁剂.口服生物膜是一种口服生物膜.红色的光是红色的光

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