神经成像 双极性障碍中感觉运动网络和视觉网络的变化及其与遗传特征的关系
Chunguo Zhang1, Yiding Han2, Haohao Yan2
1Department of Psychiatry, The Third People's Hospital of Foshan, Foshan 528000, China.
Biomedicines
|April 29, 2025
概括
感觉运动网络 (SMN) 的功能连接 (FC) 变化可能表明双相情感障碍 (BD). 基因分析揭示了SMN FC变化的共享基因,为BD提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 双极性障碍 (BD) 与各种神经网络中大脑活动的改变有关.
- 了解功能连接 (FC) 变化及其在 BD 中的遗传基础至关重要.
研究的目的:
- 在双相情感障碍 (BD) 中调查感觉运动网络 (SMN) 和视觉网络 (VN) 的功能连接 (FC) 改变.
- 探索这些FC变化的神经成像同质性,异质性和遗传关联.
主要方法:
- 在77名BD患者和83名健康对照 (HCs) 中分析了基于种子和全脑FC.
- 检查遗传关联与神经成像发现在SMN和VN.
- 在BD患者治疗三个月之前和之后的FC比较.
主要成果:
- 与HC相比,BD患者在SMN和VN中表现出异常的FC.
- 在BD治疗三个月后,没有观察到SMN和VN FC的显著变化.
- 丰富分析显示了SMN FC变化的共享基因,但不是VN FC变化的共享基因.
结论:
- 改变的SMN FC可能代表双极性障碍 (BD) 的潜在神经成像生物标志物.
- 基因神经成像关联分析提供了对BD中FC变化背后的分子机制的全面了解.
更多相关视频
05:14Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
Published on: September 8, 2021
3.1K
13:08Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
8.8K
相关概念视频
Bipolar Disorder
40
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
40
Human Genetics
485
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
485
Biological Causes of Schizophrenia
27
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
27
Brain Imaging
197
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
197
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
294
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
294
Mania and Antimanic Drugs: Overview
106
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
106
