血管功能和未来冠状动脉疾病风险的标记物在马来西亚人中具有个体心血管风险因素
Amilia Aminuddin1, Nina Diyana Rusanuar1, Md Rizman Md Lazin Md Lazim2
1Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Biomedicines
|April 29, 2025
概括
脉冲波速率 (PWV) 和增强指数 (AI) 等中央血管标记器有效检测冠状动脉疾病 (CAD) 风险,而指纹光多动脉扫描健身指数 (PPGF) 等外围指标则为微血管功能提供了洞察力,特别是在失脂症中.
科学领域:
- 心血管生理学心血管生理学
- 血管生物学 血管生物学
- 生物医学工程 生物医学工程
背景情况:
- 血管功能标志物,包括中央 (PWV,AI) 和外周 (PPGF),检测与冠状动脉疾病 (CAD) 风险因素相关的早期血管损伤.
- 高血压 (HPT),脂质障碍和肥胖是与血管功能障碍相关的显著CAD风险因素.
- 在不同风险因素组中比较这些血管标志物对于理解它们的临床相关性至关重要.
研究的目的:
- 为了比较中枢和外围血管功能标志物水平,在高血压,脂质失调和肥胖的受试者中.
- 确定这些群体内的血管功能标志物和CAD风险因素之间的关系.
- 评估PWV,AI和PPGF在评估患有常见CAD风险因素的个体血管健康方面的实用性.
主要方法:
- 招募了320名受试者,包括健康的对照组和患有CAD风险因素的个人.
- 使用手指光电显微镜健身指数 (PPGF) 评估周围血管功能.
- 测量中央血管标记物,包括脉冲波速度 (PWV) 和增强指数 (AI),并计算弗雷明汉风险评分 (FRS).
主要成果:
- 与对照人群相比,高血压患者的PWV和AI显著增加.
- 两组之间没有观察到PPGF水平的显著差异.
- 在高血压和失脂症组中,PWV与FRS相关;在肥胖组中,AI与FRS相关. 在失脂症症中,PPGF与PWV和AI相关.
结论:
- PWV和AI是动脉硬和与CAD风险相关的全身血管抵抗的可靠宏血管标志物.
- 微血管标记物PPGF为内皮功能障碍和微循环问题提供了宝贵的见解,特别是在失脂症中.
- 综合中央和外围血管评估可以提供心血管风险的全面评估.
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