胰岛素饮食通过增加阿克尔曼西亚和改善肠道屏障来缓解腹腔大动脉动脉瘤
Shuang Guo1,2,3,4, Fen Yang1,2,3, Jiyu Zhang1,2,3
1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.
Biomedicines
|April 29, 2025
概括
富含纤维的饮食富含胰岛素,而不是纤维素,有效地减少了小鼠腹腔大动脉瘤 (AAA) 的扩大. 这种好处源于阿克尔曼西亚细菌的增加,改善肠道屏障功能和减少炎症.
科学领域:
- 心血管研究研究心血管研究
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 以前的研究表明,高纤维饮食对腹腔大动脉动脉瘤 (AAA) 有多种影响.
- 了解特定的纤维类型和机制对于AAA预防和治疗至关重要.
研究的目的:
- 为了确定哪种高纤维饮食可以在小鼠中预防AAA.
- 阐明对AAA的饮食保护的基本机制.
主要方法:
- 在小鼠AAA模型中对胰岛素,纤维素和食进行比较.
- 评估动脉瘤进展,炎症标志物,免疫细胞透和肠道微生物群.
- 评估肠道屏障功能和全身炎症标志物.
主要成果:
- 与纤维素和饮食相比,胰岛素饮食显著降低了AAA扩大,弹性质降解和MMP表达.
- 胰岛素丰富了阿克尔曼西亚,增强了肠道屏障功能,并减少了全身炎症 (脂多糖,IL-1β).
- 单独给阿克尔曼西亚缓解了AAA,这表明它在保护作用中的关键作用.
结论:
- 可发酵纤维的胰岛素,与纤维素不同,在小鼠中减轻了AAA.
- 保护作用通过增加阿克尔曼西亚,改善肠道屏障完整性和调节炎症反应来调节.
更多相关视频
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
253
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
253
01:17Drugs for Treatment of Diarrhea-Predominant IBS
126
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
126
01:21Inflammatory Bowel Disease V: Surgical Management
67
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
67