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Updated: May 9, 2025

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OCA-B促进干状CD4+T细胞的致病成熟和自身免疫性脱髓化

Erik P Hughes1, Amber R Syage1, Elnaz Mirzaei Mehrabad2

  • 1Department of Pathology, University of Utah School of Medicine, Salt Lake City, United States of America.

The Journal of clinical investigation
|April 29, 2025
PubMed
概括

转录协调器OCA-B驱动干细胞类CD4+T细胞的致病成熟,促进多发性硬化症的自身免疫性脱髓化. 它的损失可以防止疾病,同时保持抗病毒免疫力.

关键词:
这是一种自身免疫力.免疫学 免疫学 免疫学多发性硬化症是多发性硬化症.在T细胞,T细胞.

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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