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Updated: May 15, 2025

The Determination of Protease Specificity in Mouse Tissue Extracts by MALDI-TOF Mass Spectrometry: Manipulating PH to Cause Specificity Changes
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通过使用小分子抑制剂的研究揭示了 site-one 蛋白酶对基质选择性的结构基础

Ashley V Bullington1, Ilaria Micallo2,3,4, Bilkish Bajaj1

  • 1Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390.

Proceedings of the National Academy of Sciences of the United States of America
|April 29, 2025
PubMed
概括

对脂质生成和ER压力至关重要的Site-one蛋白酶 (S1P) 活性进行了研究,使用抑制剂PF-429242. 结构分析揭示了S1P如何识别基质,使得S1P可设计出耐药的S1P变体.

关键词:
这是春天的春天.胆固醇 胆固醇 胆固醇 是一种低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.蛋白质酶是一种蛋白质酶.站点-1-蛋白酶的位置.

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