基线肺功能和发生结核病的风险:全国性基于人口的队列研究
Kyu Yean Kim1, Yong-Moon Park2, Seung Hyun Ko3
1Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
肺功能受损,包括阻塞性或限制性模式,与患结核病 (TB) 的风险更高有关. 在一秒内降低强迫呼气体积 (FEV1) 显著增加结核病发病率.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 呼吸系统健康 呼吸系统健康
背景情况:
- 众所周知,肺结核 (TB) 会导致肺功能下降.
- 然而,基线肺功能与一般人群患结核病的风险之间的关联仍然不清楚.
研究的目的:
- 调查基线肺功能与发生结核病的风险之间的关系.
- 评估是否先前存在的肺功能障碍预测了结核病的发展.
主要方法:
- 一项基于全国人口的队列研究利用了2010-2016年的数据.
- 包括16,594名40岁以上的参与者,具有螺旋计数据,没有先前的结核病史.
- 发生结核病是主要终点,随访时间中位数为5.5年.
主要成果:
- 在16457名参与者中,出现了72例新的结核病诊断.
- 阻塞性和限制性肺功能障碍与结核病风险翻倍相关 (aHR:分别为2.033和2.193).
- 一秒内强迫呼吸量下降 (FEV1) 显示了与增加结核病风险的剂量反应关系 (趋势p<0.0001).
结论:
- 基本肺功能受损是发展结核病的重要危险因素.
- 降低FEV1水平与结核病风险相反相关,这表明它对最佳肺功能起着保护作用.
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