关于儿童代谢功能障碍相关脂肪性肝病的评估和管理的AASLD实践声明
Stavra A Xanthakos1, Samar Ibrahim2, Kathryn Adams3
1Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Hepatology (Baltimore, Md.)
|April 29, 2025
概括
本实践陈述提供了关于儿科代谢功能障碍相关的脂肪性肝病 (MASLD) 的指导,解决了它在儿童中的独特方面. 它提供基于证据的诊断,治疗和护理建议,强调与心脏代谢健康的联系.
科学领域:
- 儿科肝病学 儿科肝病学
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 肝脏病理病理 肝脏病理病理
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 在儿童中非常普遍.
- 与成人疾病相比,儿科MASLD表现出明显的流行病学,临床和组织病理学特征.
- 2023年命名规范的修订强调肝硬化和心脏代谢风险因素.
研究的目的:
- 为MASLD.制定一个以儿科为重点的基于证据的实践陈述.
- 为儿科MASLD的临床护理和研究提供结构化的指导.
- 突出关键概念,包括诊断标准,非侵入性评估和治疗方法.
主要方法:
- 一个多学科的写作小组进行了全面的PubMed文献搜索,截至2024年3月6日.
- 审查了涉及儿童参与者 (0-18岁) 患有NAFLD或MASLD的研究.
- 基于证据的实践陈述是使用最高可用的证据水平来制定的,在必要时补充了专家的共识.
主要成果:
- 开发了30份以证据为指导的实践陈述.
- 突出了与儿科MASLD相关的关键概念.
- 确定了关键的知识差距,以告知未来的研究.
结论:
- 本实践陈述为推进儿科MASLD的临床护理和研究提供了一个结构化的框架.
- 它强调了评估肝硬化和相关心脏代谢风险因素的重要性.
- 该文件涉及儿科MASLD的流行病学,病理生理学,诊断,治疗和护理过渡.
相关概念视频
01:29Chronic Pancreatitis II: Collaborative Care
46
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
46
01:30Liver Physiology
378
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
378
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
49
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
49
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:24Overview of Lipid Metabolism
789
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
789